On Sample Size Calculation for Comparing Survival Curves Under General Hypothesis Testing
نویسندگان
چکیده
منابع مشابه
Sample Size Calculation for Comparing Variabilities
In practice, the variabilities of responses involved in clinical research can be roughly divided into three categories. They are, namely, intra-subject, inter-subject, and total variabilities (1). More specifically, the intrasubject variability is the variability observed by repeated measurements on the same subject under exactly the same experiment conditions. This type of variability is very ...
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Sample size calculation plays an important role in clinical research. In clinical research, a sufficient number of patients is necessary to ensure the validity and the success of an intended trial. From a statistical point of view, if a clinically meaningful difference between a study treatment and a control truly exists, such a difference can always be detected with an arbitrary power as long ...
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Mid-study design modifications are becoming increasingly accepted in confirmatory clinical trials, so long as appropriate methods are applied such that error rates are controlled. It is therefore unfortunate that the important case of time-to-event endpoints is not easily handled by the standard theory. We analyze current methods that allow design modifications to be based on the full interim d...
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In clinical research, parameters required for sample size calculation are usually unknown. A typical approach is to use estimates from some pilot studies as the true parameters in the calculation. This approach, however, does not take into consideration sampling error. Thus, the resulting sample size could be misleading if the sampling error is substantial. As an alternative, we suggest a Bayes...
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ژورنال
عنوان ژورنال: Journal of Biopharmaceutical Statistics
سال: 2012
ISSN: 1054-3406,1520-5711
DOI: 10.1080/10543406.2010.550701